Zeta potential, particle size, and molecular weight are three of the most important parameters for the colloid and polymer chemist
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Zetasizer Nano Series

Zetasizer Nano series for Particle Size, Zeta Potential, and Molecular Weight Measurement

The new Zetasizer Nano series can measure a combination of three of the most important parameters for the colloid and polymer chemist, particle size, zeta potential and molecular weight.

The new technology incorporated in these systems provides unequalled sensitivity and versatility. The patented NIBS optics incorporated into the Nano Z and Nano ZS also allows measurements of samples with little or no dilution.

  • Particle size - NIBS technology enables measurements of particles and molecules from 0.6nm to 6 microns.
  • Zeta potential - M3-PALS technology enables accurate measurements of zeta potential in aqueous and non-aqueous dispersions.
  • Molecular weight - An avalanche-photodiode detector and fibre detection optics give the sensitivity and stability required for absolute molecular weight measurement.

The Zetasizer Nano ZS is the pinnacle of the Malvern Zetasizer Nano series and can measure all three parameters with no performance compromises.

The Nano ZS, Z and ZS90 can all use the unique disposable zeta potential cell to ensure no cross contamination of samples.

All systems are compatible with the MPT-2 autotitrator to enable trend measurements and sample preparation to be automated.
  Zeta
potential measurement*		 Particle size range* Molecular weight range*
Zetasizer Nano ZS M3-PALS
5nm - 10µm		 NIBS
0.6nm - 6µm		 1000 - 2x107 Da
Zetasizer Nano S - NIBS
0.6nm - 6µm		 1000 - 2x107 Da
Zetasizer Nano Z M3-PALS
5nm - 10µm		 - -
Zetasizer Nano ZS90 M3-PALS
5nm - 10µm		 1nm - 3µm 10,000 - 2x107 Da
Zetasizer Nano S90 - 1nm - 3µm 10,000 - 2x107 Da

* Sample dependent
   
 
Accessories for simplified measurement of zeta potential, particle size, and molecular weightDatasheet for simplified measurement of zeta potential, particle size, and molecular weight
     

Size measurement
Particle size range:

0.6nm - 6µm*

     
  1nm - 3 µm*

     
Minimum sample volume:

  12µL

      
  20µL

    
Sample concentration range:

   0.1mg/mL Lysozyme to 40%w/v*
      
Size measurement in continuous flow for use as SEC chromatography detector :

   Flow rate maximum 1mL/min
     

 

Zeta measurement

          
Particle size range :

   5 nm - 10 µm *.

    
Minimum sample volume:

   0.75 mL.

    

 

Molecular weight measurement

          
Molecular weight range:

   1x103 Da - 2x107 Da*

      


  1x104 Da - 2x107 Da

      
Minimum sample volume:

   12µL.

      


  20µL.

      
Minimum volume for automated measurement:

  2.5mL.

      

 

Trend measurement

          
Standard:

   Size Vs Time

 
  Size Vs Temperature

  
  Zeta potential Vs Time

    
  Zeta potential Vs Temperature

   
Using optional MPT-2 autotitrator:

   Size as a function of pH, conductivity or additive concentration

  
  Intensity as a function of pH, conductivity or additive concentration

  
  Zeta potential as a function of pH, conductivity or additive concentration

 

General specifications

          
Temperature range:

   2ºC to 90ºC, over full range of ambient temps
Condensation control:

   Purge facility using dry air.
Refractive index compensation for zeta potential dispersants:

  1.2 to 1.65

    
Patents granted:

   NIBS
DE 19725211
US 6,016,195
JP 2,911,877
EP 0 884 580 designated GB, FR, AU, SW, BE

  
  M3 "High & Low Frequency Electrophoresis"
GB 2,361,772
EP 1 154 266 designated DE, FR
US 09/843339
JP 2001-134510
Laser:

   4mW He-Ne, 633nm
Laser attenuator :   Automatic, transmission 100% to 0.0003%
Detector :

   Avalanche photodiode,Q.E > 50% at 633nm
 
Product laser class:

   Class 1 compliant, EN 60825-1:2001 and CDRH
Size :

   320mm, 600mm, 260mm (W,D,H)
Weight :

   20kg
Recommended computer specification:

   Pentium PC 2GHz, 128MByte RAM, 80MByte free hard disk space, 1024 x 768 screen resolution, CD-ROM drive, Windows 2000 ( Service pack 3 or higher) or XP professional (Service pack 1a or higher). One free USB port, Please Note: Windows XP is strongly recommended as the preferred Operating System platform.

Note. A laptop computer with a USB port can be used with all Zetasizer Nano systems and MPT-2 autotitrator.

 

Options

          
50mW 532nm laser as replacement for standard He-Ne Laser:

   For the measurement of samples not compatible with the standard 633nm He-Ne laser
Narrow band filter:

   To improve signal quality for fluorescent samples

Advanced data processing software:

   Manual correlator control and data selection. Choice of data filtration algorithms, correlator operating modes, zeta potential calculation method. Addition of further reports, graph types, size distribution algorithms. Selection of extra correlation channels.

Regulatory compliance:

   21 CFR part 11 operating mode software.
Extended temperature:

   Increase of temperature range to 2°C - 120°C .

 

Site requirements

         
Power requirements:

   AC 100-240V, 50-60Hz.
Ambient operating Temperature:

   10ºC - 35ºC.

Humidity :

   10 – 90% non-condensing.

Location:

   Normal laboratory conditions, out of direct sunlight.
Dry air for operation at temperatures below the dew point :

   DIN8573-1, oil class 1, water class 3, pressure 200+/-20kPag. Fitting M5 female thread to BS3643.

 

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