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Biomolecular Structure and Function

I want to measure Biomolecular Structure and Function

The functional activity of proteins, and other biomolecules, is directly linked to their structure. Biophysical methods have traditionally provided dislocated measurement of either function or structure without being able to connect the two directly. Dual Polarisation Interferometry (DPI), the core technology of the AnaLight instrument range, is an optical technique that combines measurement of both structure and function in one data set, at sub-molecular levels of resolution and in real time.

The unique, absolute measurements of molecular dimension, fold density and mass provided by DPI enable the researcher to question and understand the intimate links between structural changes in proteins and their functions and interactions to an extent not available fusing other laboratory-based instruments.

As an interferometric technique, DPI has a wide dynamic range so can accommodate a broad range of typical solvents, such as DMSO and EtOH, buffers and buffer additives. This means that the DPI user can carry out experiments in the conditions of choice with minimal constraints on experimental design.

Application areas for DPI within biophysical characterisation include

Protein - small molecule interactions

Protein - metal ion interactions

Lipid - protein interactions

Biomolecular structure and stability

I want to measure:


	AnaLight Bio200: The AnaLight Bio200 is designed to bring DPI's unique biomolecular structure-function measurements into development and discovery research facilities with a range of biophysical applications.


	AnaLight BioFlex: The AnaLight BioFlex brings DPI's unique biomolecular structure-function measurements into discovery and development facilities with a need for automated sample throughput in a range of biophysical applications.


	Zetasizer Nano: The Zetasizer Nano can characterize proteins and biomolecules in solution. Dynamic light scattering may be used to determine the oligomeric state and check the homogeneity of your protein.